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spectrin α2  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology spectrin α2
    A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for <t>α2</t> <t>spectrin</t> in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm
    Spectrin α2, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 102 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/spectrin α2/product/Santa Cruz Biotechnology
    Average 93 stars, based on 102 article reviews
    spectrin α2 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Lipid scrambling via TMEM16F mediates the formation and release of apoptotic vesicles"

    Article Title: Lipid scrambling via TMEM16F mediates the formation and release of apoptotic vesicles

    Journal: bioRxiv

    doi: 10.1101/2025.05.14.654002

    A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for α2 spectrin in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm
    Figure Legend Snippet: A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for α2 spectrin in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm

    Techniques Used: Expressing, Western Blot



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    A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for <t>α2</t> <t>spectrin</t> in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm
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    A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for <t>α2</t> <t>spectrin</t> in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm
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    A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for <t>α2</t> <t>spectrin</t> in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm
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    Image Search Results


    A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for α2 spectrin in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm

    Journal: bioRxiv

    Article Title: Lipid scrambling via TMEM16F mediates the formation and release of apoptotic vesicles

    doi: 10.1101/2025.05.14.654002

    Figure Lengend Snippet: A) WT/YA/YQ TMEM16F-mCherry and LifeAct-GFP-expressing HeLa cells were labelled live for exposed PS AnV. B) Analysis/quantification of F-actin in induced cells. C) Western blotting for α2 spectrin in HeLa cells. Intact spectrin and products of its degradation indicated. D) WT/YA/YQ inducible HeLa cells treated with blebbistatin, a caspase inhibitor (Q-VD-OPh) or calpeptin labelled with AnV. E) Vesicle quantification upon blebbistatin treatment of inducible HeLa cells. F) Vesicle quantification in inducible Jurkat cells. G) Vesicle quantification upon caspase inhibitor treatment of inducible HeLa cells. H) Vesicle quantification upon caspase inhibitor treatment of inducible Jurkat cells. I) Vesicle quantification in calpeptin treated inducible HeLa cells. J) Vesicle quantification in calpeptin treated of inducible Jurkat cells. All scale bars: 20 μm

    Article Snippet: Primary antibodies used were: 1:1000 spectrin α2 (Santa Cruz, sc-48382), 0.4 μg/mL GAPDH (Sigma; Cat# MAB374).

    Techniques: Expressing, Western Blot